在真核生物中，调控性ncRNA的发现路径较为曲折。1990年，首个长非编码RNA（lncRNA）H19被鉴定，其虽具mRNA特征却无编码能力，并证实对胚胎发育至关重要。然而，真核小RNA的存在直至1993年才通过线虫中的lin-4 RNA得以揭示，其通过靶向mRNA的3‘UTR抑制翻译。随后let-7 ...

Schematic representation summarising MASLD-associated long non-coding RNAs (lncRNAs) and their relevant targets in hepatocytes: human leukocyte antigen (HLA) complex group 18 (HCG18), nuclear enriched ...

Long non-coding RNAs (lncRNA) are a type of RNA molecule that do not carry instructions to make proteins. Instead, they influence how other genes are expressed. There are tens of thousands of lncRNAs ...

Explore how aggressive breast cancer evades immune defences and discover potential treatment strategies with our latest ...

Researchers uncover a cunning new trick by which breast cancer cells evade immune attack. While the cGAS-STING pathway normally detects cytosolic DNA and activates anti-tumor immunity via ...